Endocrine Abstracts

Context: Many pediatric cancer survivors have endocrine conditions. After alkylating agents, steroids, methotrexate and radiation, several endocrine dysfunctions may appear. Surveillance for late effects is recommended by worldwide guidelines.Objective: The objective of the study was to describe the endocrine outcomes of 764 patients followed during a 20 years period in our out-patient clinic.Design: The design was a retrospective ...

Introduction: The somatotropin deficit is one of the late consequences of cancer treatments. The administration of somatotropin implies treatment with daily injections, which hinders therapeutic adherence. This goal is a challenge for survivors and health professionals. Therapeutic education and new technologies are instruments that favor the training and development of control mechanisms that promote and motivate the behavior’s change.Objective: To...

Introduction: In our country somatropin treatment is supported by the National Health Service. A National Committee (CNNHC) rules and analysis the submission papers of patients with: isolated/multiple somatotropin deficiency (STD), short stature in: renal chronic disease (DRC), small for gestational age (SGA), Turner syndrome (TS) and Prader Willi syndrome (PWS). In adults only isolated somatropin deficiency diagnosed in childhood.Aims: To analyze the ch...

Introduction: Treatment with recombinant Somatropin (rSMT) is safe and has greatly improved the approach of children and adolescents with somatropin deficiency (SMTD) and other growth disorders. In our country, rSMT therapy is approved for isolated/multiple somatropin deficiency, small for gestational age (SGA), chronic kidney disease (CKD), Turner syndrome (TS) and Prader Willi syndrome (PWS). A National Commitee (CNNHC) is responsible for the analysis of each case and treatm...

Background: Papillary thyroid cancer (PTC) is the most common type of thyroid carcinoma, but it rarely presents as an intrathoracic mass with concurrent hyperthyroidism due to Graves disease.Case presentation: A 73-year-old man presented with weight loss. Imaging by computed tomography (CT) documented a large mediastinal mass in the infrathyroidal space separate from the thyroid gland and pulmonary lesions suggestive of metastases. Neck ultrasound showed...

Introduction: Hodgkin lymphoma (HL) survivors may develop a range of long-term complications that arise years after therapy. Among these, the endocrine dysfunctions are a major concern. Aim: To investigate the long-term endocrine effects of HL treatment.Methods: Revision of the HL patients’ medical files who were followed at our Endocrine Late-effects Clinics.Results: We studied 178 patients (86 (48.3%) were female), whose mea...

Introduction: Chemotherapy may be an important cause of primary infertility, especially in girls submitted to this therapy at very young ages.Clinical case: A 20-year-old female was diagnosed with acute lymphoblastic leukaemia at the age of 1. She was submitted to chemotherapy: intrathecal methotrexate and cyclophosphamide and i.v. doxorubicin, vincristine, mercaptopurine, asparaginase and bone marrow transplantation at the age of 2. She was ref...

Introduction: Asparaginase is a component of chemotherapy regimens used to treat paediatric acute lymphoblastic leukaemia (ALL). One of its well-known side effects is hyperglycaemia which is probably related to hypoinsulinemia. Its incidence rises significantly when associated with corticotherapy. We present two cases of diabetes related to asparaginase and corticoid administration.Case 1: Eleven-year-old girl diagnosed with an ALL. Before treatment she ...